Optimal Control of Dengue Transmission with Vaccination

Dengue disease is caused by four serotypes of the dengue virus: DEN-1, DEN-2, DEN-3, and DEN-4. The chimeric yellow fever tetravalent vaccine (CYD-TDV) a currently used in Thailand. This research investigates what optimal control when only individuals having documented past infection history are vaccinated. present practice Thailand latest recommendation WHO. model Susceptible-Infected-Recovered (SIR) series configuration for human population Susceptible-Infected (SI) vector population. Both dynamical models two populations were recast as problems with parameters. analysis showed that equilibrium states locally asymptotically stable. numerical solution systems conclusions presented.